Our Research

The following is a list of our active clinical trials. For more information please refer to the contact information for each individual study.

 

Parkinson’s Disease

Stroke

Traumatic Brain Injury

Spinal Cord

Chronic Pain

Aging

Nursing

Other

 


Parkinson’s Disease

  • “Accuracy of Examining Cough Function and Its Relationship to Airway Protection in Those with Parkinson’s Disease”
    • Principle Investigator: Christine Sapienza, Ph.D., Jacksonville University
    • Purpose of Study: This non-therapeutic investigation will compare peak cough airflow values to observed penetration-aspiration (P/A) scores (collected during standard-of-care Modified Barium Swallow examination prior to participants’ entrance in the study) in order to determine if non-invasive measures of peak cough airflow can be used to predict P/A scores in individuals with neurodegenerative/neurogenic disease.
    • Participant Inclusion/Exclusion Criteria:
      • Diagnosis of PD
      • Between 30 and 80 years of age
      • Non-smoking or no smoking within previous 5 years
      • No history of head or neck cancer, asthma, COPD or untreated hypertension
      • Normal cognition
      • No neurological (other than PD) condition which adversely affects respiratory muscle or gas system exchange
    • Compensation: Available
    • Study Location and Contact: This study will be conducted through the Brooks Rehabilitation Clinical Research Center, located at 3901 University Blvd. South, Suite 101, Jacksonville, FL 32216. All swallowing evaluations will be performed at Memorial Hospital of Jacksonville. Brooks Contact: Floris Singletary, Research manager, 904-345-8973 or flo.singletary@brooksrehab.org

 

  • “Cough and Swallow Rehabilitation Following Stroke”
    • Principle Investigator: Karen Hegland, Ph.D., University of Florida
    • Purpose of Study: The purpose of this research study is to determine the effects of a training program for increasing the strength of the muscles used for breathing, coughing and swallowing in patients who have had a stroke. In addition, the study will help us to understand how changing the strength of the breathing muscles influences breathing, coughing and swallowing.
    • Participant Inclusion/Exclusion Criteria:
      • Diagnosis of stroke within the last year
      • Neurologic status permits participation
      • Medical status permits participation
      • No history of head or neck cancer, multiple strokes or cardiac valve thrombosis
      • No history of dysphasia secondary to something other than stroke
    • Compensation: Available
    • Study Location and Contact: This study will be conducted through the Brooks Rehabilitation Clinical Research Center, located at 3901 University Blvd. South, Suite 101, Jacksonville, FL 32216 Brooks Contact: Floris Singletary, Research manager, 904-345-8973 or flo.singletary@brooksrehab.org
 
  • “Rehabilitation of Corticospinal Control of Walking Following Stroke”
    • Principle Investigator: David J. Clark, ScD, University of Florida, VA
    • Purpose of Study: The objective of this project is to compare the effects of two training interventions: typical steady state walking (TYP training) versus accurate gait modification task training (ACC training). This study will assess the effects on walking function and the underlying neural impairments in individuals who are 6 months post-stroke. 
    • Participant Inclusion/Exclusion Criteria:
      • Between 18 and 80 years of age
      • Diagnosis of single unilateral stroke in previous 6 months
      • Approval of participation by primary care physician
      • No severe perceptual or cognitive deficits
      • No significant lower extremity joint pain
      • No serious cardiac conditions or surgery in the previous 6 months
      • No history of severe pulmonary disease
      • No neurological conditions other than single stroke
      • No major depression, severe obesity or severe hypertension
    • Study Location and Contact: The interventions will be conducted at Brooks Rehabilitation Clinical Research Center, located at 3901 University Blvd. South, Suite 101, Jacksonville, FL 32216. Assessments will be conducted at the VA BRRC in Gainesville, FL. Brooks Contact: Floris Singletary, Research manager, 904-345-8973 or flo.singletary@brooksrehab.org
 
  • ”Mechanisms of Gait Variability Post-stroke”
    • Principle Investigator: Chitralakshmi K. Balasubramanian PT, Ph.D., University of North Florida
    • Purpose of Study: The purpose of this study is to investigate mechanisms of gait variability in persons with stroke. Current evidence suggests that gait variability is a quantifiable marker to evaluate walking impairment and is related to the risk for falls. Earlier research conducted by the PI showed that step variability is altered in individuals with stroke compared to healthy adults and that variability relates to walking related deficits. However, underlying mechanisms of gait variability have not been explored. Investigation of underlying mechanisms could help develop appropriate treatment interventions.
    • Participant Inclusion/Exclusion Criteria:
      • At least 6 months post-stroke
      • Have unilateral weakness
      • Are able to walk 10 m in 50 seconds or less without assistance by another person
      • Have no severe perceptual, cognitive or cardiovascular impairment that could affect walking
      • Able to follow verbal requests for movement or tasks
      • No other neurological conditions in addition to stroke
      • No unstable cardiovascular disease or severe cardiorespiratory symptoms
      • Suffered no more than one cerebrovascular incident
    • Compensation: There are no monetary compensations or inducements for taking part in this study. However, your transportation to the UNF Laboratory will be covered on case by case bases.

 

    • Study Location and Contact: Testing will be conducted indoors in the UNF Clinical and Applied Movement Sciences (CAMS) Research Laboratory on-campus in Jacksonville, FL. Brooks Contact: Floris Singletary, Research manager, 904-345-8973 or flo.singletary@brooksrehab.org

 

  • “Motor Impairments in Traumatic Brain Injury: Effects of Callosal Disconnection”
    • Principle Investigator: Adam D. Falchook MD, University of Florida, VA BRRC
    • Purpose of Study: This study is looking to learn about the different types of motor impairments that can occur after traumatic brain injury. Specifically the motor impairments resultant from dysfunction of the left hemisphere praxis systems and right hemisphere action- intention systems as well as those attributable to callosal disconnection.
    • Participant Inclusion/Exclusion Criteria:
      • Between 18 and 50 years of age
      • History of closed head trauma resulting in loss of consciousness >24 hours
      • No spinal cord injury or peripheral injuries that may interfere with participation
      • Cognitively able to give informed consent
    • Compensation: Available
    • Study Location and Contact: This study will be conducted through the Brooks Rehabilitation Clinical Research Center, located at 3901 University Blvd. South, Suite 101, Jacksonville, FL 32216 Brooks Contact: Floris Singletary, Research manager, 904-345-8973 or flo.singletary@brooksrehab.org
 
  • “The Effect of Goal Management Training with Mild TBI Veterans”
    • Principle Investigator: J. Kay Waid-Ebbs, Ph.D., University of Florida, VA BRRC
    • Purpose of Study: test an innovative treatment for executive dysfunction in veterans with mild traumatic brain injury that utilizes formalized and manualized procedures that can be exported for use in a subsequent randomized clinical trial.
    • Participant Inclusion/Exclusion Criteria:
      • Diagnosis of mild TBI according to the American Congress of Rehabilitation Medicine
      • Age 18-55 years
      • At least 4 months post injury
      • Family member or friend that is will to provide feedback
      • No history of pre-morbid learning disability
      • No history of psychiatric diagnosis sufficiently severe to have resulted in inpatient hospitalization
      • No history of neurological disease unrelated to TBI
      • No history of alcohol or substance abuse within the past year
    • Compensation: Available
    • Study Location and Contact: This study will be taking place in Gainesville, FL at the VA BRRC. Brooks Contact: Floris Singletary, Research manager, 904-345-8973 or flo.singletary@brooksrehab.org

 

  • “Validation through Concurrent Use of Spiritual Wellness Assessment with Spinal Cord Injured Inpatients at Three Rehabilitation Facilities”
    • Principle Investigator: Re. Hazel Thomas, BCC, University of Texas
    • Purpose of Study: The purpose of this study is to evaluate the use of the Spiritual Wellness Assessment (SWA) in measuring change in spiritual wellness over the initial inpatient rehabilitation stay among people with spinal cord injury (SCI). The SWA is being used as standard of care in chaplain services with spinal cord injured patients who have not been previously hospitalized for rehabilitation.
    • Participant Inclusion/Exclusion Criteria:
      • Age 18 and over
      • First time spinal cord injury patients currently hospitalized at Brooks Rehabilitation Hospital
      • Cognitively capable of giving informed consent and communicating independently
      • Cannot have a dual diagnosis of SCI/TBI
    • Compensation: You will not be paid for taking part in this study.
    • Study Location and Contact: This study will take place in Brooks Rehabilitation Hospital located at 3599 University Blvd. South, Jacksonville, FL 32216. Brooks Contact: Floris Singletary, Research manager, 904-345-8973 or flo.singletary@brooksrehab.org

 

 

  •  “Creation of the Orthopedic Physical Therapy – Investigative Network (OPT-IN) for the Optimal Screening for Prediction of Referral and Outcome (OSPRO) Cohort Study”
    • Principle Investigator: Steven George PT, Ph.D., University of Florida
    • Purpose of Study:The purpose of this study is to develop a new questionnaire to direct physical therapy management of individuals seeking care for complaints at the back, neck, knee and shoulder.
    • Participant Inclusion/Exclusion Criteria:
      • Between 18 and 70 years of age
      • Seeking outpatient physical therapy treatment for musculoskeletal pain of the cervical spine, lumbar spine, shoulder or knee.
      • Able to read and comprehend English language
      • No history of widespread chronic pain syndrome or neuropathic pain syndrome
      • No history of psychiatric care, current cancer treatment or neurological disorder
    • Compensation: Available
    • Study Location and Contact: This study will take place at clinical sites from Shands and Brooks Health Systems with later expansion outside of Florida

 

  • “The Lifestyle Interventions and Independence for Elders (LIFE) Study”
    • Principle Investigator: Todd Manini, Ph.D., University of Florida
    • Purpose of Study: The purpose of this research study is to find out how older people can make changes in their lives that will help them to remain independent members of their communities for a longer period of time.
    • Participant Inclusion/Exclusion Criteria: This study is no longer recruiting for participants.
    • Compensation: Available
    • Study Location and Contact:The assessments for this study are taking place at Brooks Rehabilitation Clinical Research Center, located at 3901 University Blvd. South, Suite 101, Jacksonville, FL 32216 Brooks Contact: Floris Singletary, Research manager, 904-345-8973 or flo.singletary@brooksrehab.org

 

  • "Falls Reduction Addressed by Nursing Continuous Education"
    • Principle Investigator: Angela Jordan, RN, BSN, CRRN
    •  Purpose of Study: This study is being done to learn more about how nurses can best decrease falls from occurring in patients who have experienced a brain injury. Nursing staff will receive additional education that is focused on preventing falls for patients who have experienced a brain injury. Patients and family will be provided an informational brochure with information to help prevent a fall.
    • Participant Inclusion/Exclusion Criteria:
      • 18 years of age or older
      • Experienced a brain injury
      • Currently in inpatient hospitalization at Brooks Rehabilitation Hospital on the Second Floor
    •  Compensation: No monetary compensation is provided
    • Study Location and Contact: The study will take place at Brooks Rehabilitation Hospital 3599 University Blvd. South, Jacksonville, FL 32216. Brooks Contact: Angela Jordan, RN, BSN, CRRN at 904-345-7700.
  • “ASPIRE: Adult SPasticity International REgistry on BOTOX® Treatment”
    • Principle Investigator: Kenneth Ngo, MD
    • Purpose of Study: The purpose of this observational study is to monitor how BOTOX® is used in routine clinical practice for the treatment of spasticity and to collect information related to the safety and effectiveness of BOTOX® in people being treated with BOTOX® for spasticity.
    • Participant Inclusion/Exclusion Criteria:
      • 18 years of age or older
      • Treated with BOTOX® according to a decision by you and your physician for newly diagnosed or established focal spasticity related to upper motor neuron syndrome;
      • Have cognitive and linguistic ability to complete study questionnaires as determined by your physician;
      • Willing and able to answer questions by phone or internet on a scheduled basis, with or without assistance of a caregiver.
    • Compensation: Available
    • Study Location and Contact: This study will take place at Brooks Physician’s Practice 3901 University Blvd. South, Suite 103, Jacksonville, FL 32216. Brooks Contact: Mallorey Smith, Study Coordinator at 904-345-8970 or mallorey.smith@brooksrehab.org